Basic studies on the influence of hemorrhage on the antimicrobial effect of visible light in a trachea model

Abstract Ventilator-associated pneumoniae (VAP) are a major problem in intensive care units. Previous vitro experiments revealed that blue or violet luminescent endotracheal tubes capable of inhibiting bacterial growth and may thus prevent pathogens from entering the lung. However, while these studies were conducted relatively transparent suspension, subglottic secretions around can also contain highly absorbent components, such as blood. To investigate if light has an antimicrobial effect under conditions, staphylococcal solutions containing various components irradiated by for up to 24 h tracheal model. Light was generated externally LEDs lasers entered tube via guides. An observed light, which was, however, inhibited some extent presence adsorbing molecules. Under had stronger than at low absorptions, strong absorptions effects converged, with even exhibiting slightly impact. Significant differences between could not be detected. In our model, inhibition absorbing Illuminating represent promising strategy migration bacteria oropharynx into trachea and, thereby, possibly decrease incidence VAP.